Background: Patient’s satisfaction with care is an important construct in determining the quality of care and adherence to treatment. This study was aimed at comparing the satisfaction level of patients with schizophrenia regarding the outpatient care in community mental health setting with that of typical psychiatric hospital and identifies factors accounting for any difference. Methods: This is a comparative cross-sectional survey of patients with the diagnosis of schizophrenia attending the outpatient clinic of the Neuropsychiatric Hospital (NPH) and the State Community Psychiatric Services Centre (OSCPSC), Oke Ilewo, both in Abeokuta, Ogun State, Nigeria. Patients’ satisfaction was assessed using the Charleston Psychiatric Outpatient Satisfaction Scale (CPOSS). Frequency distribution, mean scores with standard deviations, independent t-test, and analysis of variance were calculated as deemed appropriate. The level of significance was set at p < 0.05. Results: Out of the 260 patients sampled, 22 opted out, thus giving a response rate of 91.5%; 121 from NPH and 117 from OSCPSC. With the exception of employment status, the two centers did not differ significantly on other socio-demographic variables. The overall mean CPOSS scores for the respondents at NPH and OSCPSC were comparable (p = 0.287). Meanwhile, participants at OSCPSC were significantly satisfied more with record officers’ help, clinic hours, waiting time, and cost of treatment (p < 0.05), while participants at NPH were significantly satisfied more with treatment center’s appearance (p = 0.001). Similarly, patients with lower level of education and females particularly those from OSCPSC are likely to be satisfied more with their care than do other categories. Conclusion: Although, patients’ overall satisfaction with out-patient care was found to be similar in both settings, patients attending OSCPSC enjoy easier access to care and relatively lower cost compared with their counterpart at NPH, who were relatively satisfied more with the appearance of the treatment center.