E-ISSN 2146-8346


Journal of Behavioral Health. 2015; 4(4):(149-295)


Unilateral lesion of fastigial nucleus in Wistar albino rats and its eff ect on motor coordination - A preliminary study

Wankupar Wankhar, Sheeladevi Rathinasamy

Abstract

Aim: The objective of this present study was to investigate whether unilateral lesion in the fastigial nucleus (deep cerebellar nuclei) which is believed to influences posture and locomotion, could alter motor coordination in a rat model. Materials and Methods: In order to understand motor activity a combination of three motor tasks, which include rotarod, grid walk, and narrow beam test were performed. Rats were divided into three groups namely control, sham, and lesion groups. Results: The lesion group on 10th day showed increased hind limbs, forelimbs slips, and time spent on grid runway and beam walk along with decrease performance in the rotarod test, which is an indicative of altered motor behavior. However, no significant change was observed on the 15th day study in the entire test. Conclusion: This transient effect displayed on the 15th day, suggest that it might have been due to the ability of the animal to rehabilitate/neuronal plasticity on the lesioned side or it may have been due the compensatory changes on the non-damaged brain areas.

Most Viewed Article
  • Defining the personal determinants of health for older adults
    Stephanie MacLeod, Sandra Kraemer, Rifky Tkatch, Annette Fellows, Laurie Albright, Michael McGinn, James Schaeffer and Charlotte S. Yeh
    » Abstract » doi: 10.5455/jbh.XXXXXX

  • Habitat Divide in the Practice of Cleanliness as Disease Prevention Measure
    Dr Hamilton-Ekeke Joy-Telu, Dr Odibo Anthony Ajakpovi, Blessing C. Cleopas, Mercy Telu
    » Abstract » doi: 10.5455/jbh.XXXXXX

  • Test Period Stress: Factor on Eating and Physical Activity in College of Nayarit Mexico
    José Enrique Jiménez-Hernández and Gilberto Mercado-Mercado
    » Abstract » doi: 10.5455/jbh.XXXXXX

  • Does the Prevailing Awareness Reflect on Hygiene Practices for Handling Fish in Zanzibar?
    Zakia M. Abubakar, Rabia, A.R, Ali M. Ussi and Asma, A. Hamad
    » Abstract » doi: 10.5455/jbh.XXXXXX

  • Occupational Therapy Assessment and Intervention of a 22 Month Old Girl with Feeding Refusal
    Berta Gándara-Gafo, Tania Moriyón-Iglesias and Isabelle Beaudry-Bellefeuille
    » Abstract » doi: 10.5455/jbh.XXXXXX

Most Downloaded
  • Defining the personal determinants of health for older adults
    Stephanie MacLeod, Sandra Kraemer, Rifky Tkatch, Annette Fellows, Laurie Albright, Michael McGinn, James Schaeffer and Charlotte S. Yeh
    » Abstract » doi: 10.5455/jbh.XXXXXX

  • Habitat Divide in the Practice of Cleanliness as Disease Prevention Measure
    Dr Hamilton-Ekeke Joy-Telu, Dr Odibo Anthony Ajakpovi, Blessing C. Cleopas, Mercy Telu
    » Abstract » doi: 10.5455/jbh.XXXXXX

  • Test Period Stress: Factor on Eating and Physical Activity in College of Nayarit Mexico
    José Enrique Jiménez-Hernández and Gilberto Mercado-Mercado
    » Abstract » doi: 10.5455/jbh.XXXXXX

  • Does the Prevailing Awareness Reflect on Hygiene Practices for Handling Fish in Zanzibar?
    Zakia M. Abubakar, Rabia, A.R, Ali M. Ussi and Asma, A. Hamad
    » Abstract » doi: 10.5455/jbh.XXXXXX

  • Occupational Therapy Assessment and Intervention of a 22 Month Old Girl with Feeding Refusal
    Berta Gándara-Gafo, Tania Moriyón-Iglesias and Isabelle Beaudry-Bellefeuille
    » Abstract » doi: 10.5455/jbh.XXXXXX