Background: Epilepsy is a common neurologic disease that causes many problems such as more costs and social problems due to negative attitudes to disease for patients. This study aimed to evaluate the knowledge and attitudes of medical and non-medical students toward epilepsy in Ardabil city, Iran. Methods: A cross-sectional descriptive survey was conducted in Ardabil city (Northwest of Iran) in 2017. One hundred and fifty students were selected randomly from all medical and non-medical students who completed the self-administered questionnaire which was provided for this study. Collected data were analyzed by statistical methods in SPSS version 19. Results: Of all students, 30% were girls and rests of them were boys. Of all students, 47.3% had moderate knowledge and 44.7% had well attitudes about epilepsy. Most of boys with 51.1% and most of girls with 45.7% had moderate knowledge but no significant difference between two sexes. Most of boys with 43.8% and most of girls with 46.7% had moderate attitudes toward epilepsy but no significant difference between two sexes. Conclusion: Results showed that most of the students in this study had moderate knowledge and good attitudes toward epilepsy.