Background: Non-steroidal anti-inflammatory drugs (NSAID’s) are the common drugs used for acute and chronic pains. Excessive and inappropriate use of these medications can be having many side effects on youth and students’ health in the future. Objective: The objective of the study was to determine the rate of NSAID’s use among university students. Materials and Methods: This descriptive cross-sectional study has been done on 400 students selected randomly from Ardabil City Universities. Data were collected by a questionnaire and then analyzed by statistical methods in SPSS 19. Results: Of all participants, 68% were male and rests of them were female. Of all students, 68.3% were in the age group of 20 through 25 and 62% of students were from medical university. From them, 69.3% had awareness about the NSAID’s. The prevalence of NSAID’s use among students was 68%. The most common causes of NSAID use was headache (38.3%) in the form of gelofen with 36.3%. Conclusion: According to the high prevalence of NSAID use between students (68%), doing more studies in future about notification educated class and youths toward contaminations of uses NSAID’s and decreasing rate of use and better medical behaviors is necessary.