Journal of Behavioral Health and Psychology. 2016; 5(4):(183-318)


Olanzapine-induced hypothermia: A rare case report

Javed Ather Siddiqui, Shazia Farheen Qureshi, Abdullah Al Zahrani

Abstract

We report a case of 40-year-old man who had a diagnose case of schizophrenia on olanzapine had develop symptomatic hypothermia. The majority of documented cases involve short duration of hypothermia often <24 h. Antipsychotics that are a more potent antagonists at 5-hydroxytryptamine 2 (5HT2) than at dopamine 2 receptors appear more likely to cause hypothermia. Hypothermia is an adverse drug reaction of antipsychotic drug use. It is strong 5HT2 antagonistic characteristics which induced hypothermia has been proposed. 55% of hypothermia reports are for atypical antipsychotics. A 40-year-old man with schizophrenia who was being treated with a therapeutic dose of olanzapine presented with shivering, slurred speech, and confusion. He had a core temperature of 31.5°C. Electrocardiogram showed sinus bradycardia with Osborn waves or J waves. He did not have any risk factors for developing hypothermia except the use of olanzapine. There was an improvement in his clinical condition with reversal of electrocardiogram changes following gradual re-warming and withhold of olanzapine. Olanzapine-induced hypothermia is rare and has been reported during initiation and increasing the dose or even in stable dose, but this case report raises the possibility of hypothermia even in the patients who are on stable doses of olanzapine for a long period of time. Clinicians should consider the possibility of drug-induced illness in hypothermic patients who are taking antipsychotics.

Most Viewed Article
  • Using Social Media Engagement to Raise Pre-Diabetes Awareness for Rural Idaho Hispanics or Latinos
    Tanna M. Woods PhD MSN RN, Heidi K. Lewis DNP RN and Mary A. Nies PhD RN FAAN FAAHB
    » Abstract » doi: 10.5455/jbh.XXXXXX

  • Evaluating the Gap of Integrated Behavioral Health Programs for NCDs in China, Vietnam, Cambodia, and Thailand
    Ronald R. O’Donnell, Jennifer Rolfes, Shiyou Wu, Mohamed Abdalla, Flavio F. Marsiglia, Pristine Mei, Pham Le An, Puchong Senanuch, Patraporn Tungpunkom, Virya Koy, Hong Tao, Kim Savuon and Rodger Kessler
    » Abstract » doi: 10.33425/2832-4579/21038

  • Occupational Therapy Assessment and Intervention of a 22 Month Old Girl with Feeding Refusal
    Berta Gándara-Gafo PhD, Tania Moriyón-Iglesias MSc and Isabelle Beaudry-Bellefeuille PhD
    » Abstract » doi: 10.33425/2832-4579/21037

  • Biological sex and Covid-19: Science versus ideology
    Carole Jahme and Ulrich Kutschera
    » Abstract » doi: 10.33425/2832-4579/21036

  • A case of chronic schizophrenia with emergent dementia: Successful medication reduction and its explication
    Grace E Jackson and Matthew Tunzi
    » Abstract » doi: 10.33425/2832-4579/21035

Most Downloaded
  • Using Social Media Engagement to Raise Pre-Diabetes Awareness for Rural Idaho Hispanics or Latinos
    Tanna M. Woods PhD MSN RN, Heidi K. Lewis DNP RN and Mary A. Nies PhD RN FAAN FAAHB
    » Abstract » doi: 10.5455/jbh.XXXXXX

  • Evaluating the Gap of Integrated Behavioral Health Programs for NCDs in China, Vietnam, Cambodia, and Thailand
    Ronald R. O’Donnell, Jennifer Rolfes, Shiyou Wu, Mohamed Abdalla, Flavio F. Marsiglia, Pristine Mei, Pham Le An, Puchong Senanuch, Patraporn Tungpunkom, Virya Koy, Hong Tao, Kim Savuon and Rodger Kessler
    » Abstract » doi: 10.33425/2832-4579/21038

  • Occupational Therapy Assessment and Intervention of a 22 Month Old Girl with Feeding Refusal
    Berta Gándara-Gafo PhD, Tania Moriyón-Iglesias MSc and Isabelle Beaudry-Bellefeuille PhD
    » Abstract » doi: 10.33425/2832-4579/21037

  • Biological sex and Covid-19: Science versus ideology
    Carole Jahme and Ulrich Kutschera
    » Abstract » doi: 10.33425/2832-4579/21036

  • A case of chronic schizophrenia with emergent dementia: Successful medication reduction and its explication
    Grace E Jackson and Matthew Tunzi
    » Abstract » doi: 10.33425/2832-4579/21035