The rapid spread of the COVID-19 pandemic in the United States was due, or at least in part, to the resistance to health guidelines, minimal to no safety measures implemented by nearly half the U.S. citizens, and, to a lesser extent, the initial lack of understanding into the pathogenic mode of transmission. The present study examined links between the Dark (i.e.., narcissism, psychopathy, Machiavellianism) and Light (i.e.., compassion, empathy, altruism) Triad of personality traits, the perceived threat level of COVID-19, and COVID-19 vaccine uptake in an undergraduate college sample (N = 147). The study found no statistically significant differences in the overall Light or Dark Triad scores between students receiving and those not receiving the COVID-19 vaccine. The vaccinated students reported a higher perceived threat level than their non-vaccinated colleagues. Implications and limitations of the study are reported. Relationships between personality, vaccine practices, and perceived health threats offer important insights. These findings may be useful in developing strategies that effectively tackle the contradictions between the psychological and the sociocultural determinants of health behavior.